Clinical background
1) Capsicium effect in case of arthritis, rheumatoid arthritis and chronic pain
Pain Research and Nuffield, Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, Headington, Oxford OX3 7LJ
The analgesic efficacy of topical capsaicin is enhanced by glyceryl trinitrate in painful osteoarthritis: a randomized, double blind, placebo
controlled study, Gary McCleane, Craigavon Area Hospital Group Trust, Craigavon, Northern Ireland
Systematic review of topical capsaicin for the treatment of chronic pain. BMJ. 2004;328:991. Epub 2004 Mar 19.
2) Capsicium effect in case of painful diabetic neuropathy
Topical Capsaicin in Painful Diabetic Neuropathy: Controlled Study With Long-Term Follow-Up Rup Tandan, MD, MRCP, Gloria A Lewis,
BS, RN, Patricia B Krusinski, BS, Gary B Badger, MS and Timothy J Fries, MD
3) Capsicium effect in case of psoriasis
Capsaicin and menthol in the treatment of itch and pain: recently cloned receptors provide the key. Gut. Sep2003;52(9):1233-5.
4) Capsicium effect in case of pruritus and other conditions
Rains C, et al. Topical Capsaicin. A Review of Its Pharmacological Properties and Therapeutic Potential in Post-herpetic Neuralgia,
Diabetic Neuropathy and Osteoarthritis. Drugs Aging. Oct1995;7(4):317-28.
Effects of Topical Application of Capsaicin to Human Skin: A Comparison of Effects Evaluated by Visual Assessment, Sensation Registration,
Skin Blood Flow and Cutaneous Impedance Measurements. Acta Derm Venereol. Mar1996;76(2):129-32.
Topical application of doxepin hydrochloride, capsaicin and a combination of both produces analgesia in chronic human neuropathic pain:
a randomized, double-blind, placebo-controlled study Gary McCleane, Pain Clinic, Craigavon Area Hospital, 68 Lurgan Road, Craigavon, BT63QQ5,
N. Ireland
The postmastectomy pain syndrome and topical capsaicin: a randomized trial. Pain. 1992;51:375-379.
Treatment of the post-mastectomy pain syndrome with topical capsaicin. Pain. 1993;54:223-226.
5) Levander effect in case of insomnia and depression
Effects of lavender on insomnia and depression in women college students,Taehan Kanho Hakhoe Chi. 2006;36(1):136-43.
6) Levander effect in case of postoperative pain
An experimental study on the effectiveness of acupressure with aromatic lavender essential oil fo r sub-acute, non-specific neck
pain in Hong Kong. Complement Ther Clin Pract. 2006;12(1):18-26.
7) Levander antibacterial and antiviral properties
Evaluation of massage with essential oils in childhood atopic eczema. Phyother Res. 2000;14(6):452-456.
This is just a brief review. For more details and studies feel free to contact us.
Safety assesment
The Capsigel was dermatologically tested evaluating the human skin compatibility by National Institute of Public health.
No evidence of primary skin irritation was detected 2 h, 24 h and 48 h after application. In some cases appeared the temporary
skin erythema, which disappear in cca 2 hours after application.
Source: Protocols No. CTZB 187-2451/11-348, Sept 2011 and Oct 2011.